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In the evaluation of cognitive decline, imaging remains a cornerstone for ruling out secondary causes and guiding differential diagnosis

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Blood testing is the most accurate way to evaluate nutrient levels

Figure 2 Several studies in recent years have shown that silencing TRFC (the gene encoding TFR1) inhibits erastin-induced iron apoptosis and prevents LIP accumulation, whereas the heme oxygenase HO-1 increases intracellular free iron levels and promotes heme degradation, which speeds up the ferroptosis process (78, 79)