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discovered that oestrogen-activated GPER in CAFs promotes the expression of GLUL and lactate dehydrogenase B (LDHB), enhances the survival of Triple Negative Breast Cancer(TNBC) cells both in vitro and ex vivo, and increases chemotherapy resistance [130]

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Such a sequence may share mechanistic features with the PRXII-GRX pathway shown in Figure 1, a principal difference being that H 2 O 2 would not react with a specific catalytic cysteine but rather in a more general way with free and reactive chloroplast protein cysteines

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Funding Statement The authors declare that no financial support was received for the research, authorship, and/or publication of this article

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