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It stems from intricate dysregulations in metabolic pathways governing energy and substrate metabolism

While no mechanism suggests delayed toxicity, this cannot be completely ruled out without long-term controlled studies

Campagna R, Cecati M, Pozzi V, Fumarola S, Pompei V, Milanese G, Galosi AB, Sartini D, Emanuelli M (2018) Involvement of transforming growth factor beta 1 in the transcriptional regulation of nicotinamide N-methyltransferase in clear cell renal cell carcinoma

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