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Tao et al., 2020

A careful history of the onset and progress of paralysis is important because gradual onset of more than two weeks' duration is strongly suggestive of a mass lesion

However, although PLP is not required for 3-MST activity, it is required for its upstream enzyme cysteine aminotransferase (CAT) to degrade cysteine to 3-mercaptopyruvate, which serves as substrate for 3-MST to produce sulfane sulfur and eventual H 2 S 10

These fatty acids are a dense, crucial source of potential energy, but they cannot cross into the mitochondrial matrixthe innermost compartment where energy production occurswithout a specialized transport mechanism