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First-generation sulfonylureas are associated with a greater risk of adverse effects, including hypoglycemia, weight gain, and fluid retention, making second-generation drugs the recommended choice in clinical practice (126, 127)

TMAO t 1/2 was estimated by fitting linear regression to log-transformed concentrations over the final three time points of each curve, corresponding to the terminal elimination phase, following standard log-linear pharmacokinetic modeling methods

Rodent studies in ulcerative colitis show significant reduction in mucosal inflammation with oral or rectal KPV administration

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