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Although the peroxidation of PUFAs in phospholipids in response to ferroptotic stimuli amplifies the number of lipid radicals produced via free radical chain reactions, ultimately leading to cell death, it is possible that antioxidants and membrane repair systems are also activated to resist ferroptosis 159,160,161,162,163

B ) Weight of WT and Aldh1l2 KO mice at 8 weeks (WT, n = 9

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In research design, there should be a transition from randomized controlled trials to personalized pragmatic randomized controlled trials, establishing appropriate clinical efficacy evaluation technologies and methods aligned with TCM characteristics through three dimensions: advantageous populations, optimized treatment protocols, and efficacy indicator systems