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This three layer device, consisting of a fibrin hydrogel cell layer, a mechanical actuation layer, and a glass cover, recapitulated joint dynamics and showed that SYN321 downregulated inflammatory markers, reduced matrix metalloproteinase activity, limited extracellular matrix degradation, and preserved microtissue architecture (Palma et al., 2024)

It is necessary to establish multi-center, cross-platform data integration systems to strengthen the connection between basic research and clinical data, improving drug prediction accuracy and therapeutic consistency [188]

Int J Cancer, 1994