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2 Freie Universitt Berlin, Faculty of Biology, Chemistry, Pharmacy, 14195 Berlin, Germany

In addition, pancytopenia is a rare manifestation of some viral infections, including the novel COVID-19 [109]

However, NOX-B11 did not affect basal food intake in nonfood-deprived rats, thus this treatment may only be efficacious when plasma ghrelin levels are high, such as before a meal or during times of food restriction (dieting).Since the discovery that the effects of ghrelin are primarily mediated by the GH secretagogue receptor (GHSR) 1a, there have been multiple potent, selective, and orally bioavailable ghrelin antagonists produced with good pharmacokinetic (PK) profiles that are currently in preclinical testing

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