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McGrath R

Arginine and Citrulline and the immune response in sepsis

later confirmed the anti-cytokine and antiviral activity of baricitinib by in-vitro experiments and reported that treatment with baricitinib improved the clinical condition in four patients with COVID-19 72

As a core regulatory factor, STAT3 can be activated by various molecules, including specific cytokines, peptide ligands, growth factors, and products of oncogenes, thereby integrating multiple signaling pathways [338, 339]