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Fourteen genes whose expression is significantly correlated with regional emphysema severity or transcription factors that are highly connected to these genes in the relevance network were selected for quantitative RT-PCR validation in a subset of tissue cores from subjects with severe emphysema (see Additional file 1 for methods)

However, the studys lack of a control group, small sample size, short follow-up, and the use of multiple simultaneous therapies limit the ability to attribute the observed benefits specifically to shock wave therapy.53 Thus, the SWT appears to be a promising therapeutic approach for lipedema, warranting further investigation through controlled trials