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It is driven by iron-dependent phospholipid peroxidation and regulated by several cellular metabolic events, including redox homeostasis, iron handling, mitochondrial activity, and metabolism of amino acids, lipids and sugars [67]

In a placebo-controlled trial in 46 COPD patients, treatment with 30 mg crocin daily for 12 weeks decreased measures of oxidative stress, increased total antioxidant capacity, and improved exercise capacity (Ghobadi 2022)

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Unmetabolized folic acid in plasma is associated with reduced natural killer cell cytotoxicity among postmenopausal women