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Immune cell exploration and ceRNA networks shed light on the underlying disease mechanisms, while molecular docking proposed luteolin, isoflavone, and thalidomide as promising therapeutic contenders (70) (Table 3)

For example, one randomized clinical trial reported a fasting-glucose shift at 2 weeks , even though the bigger VAT and liver-fat outcomes were still assessed over 6 months

Mitochondrial dysfunction in Kupffer cells plays a central role: IR causes Kupffer cell mitochondria to release mtDNA and ROS, activating NLRP3 inflammasomes which then release IL-1 that amplifies neutrophil recruitment (67)

Positive results from a clinical trial involving Japanese men revealed a notable reduction in prostate cancer incidence following the oral administration of 60 mg/day isoflavones (Miyanaga et al