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The HPLC purity of samples was determined using the UV chromatogram extracted at a 254 nm wavelength

In addition, heatmap analysis was employed to illustrate metabolic profile of treatment groups, which was implemented with the pheatmap package in R program

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Methods: We analyzed 126 patients admitted to our stroke unit between January and May,dividing them into three etiological groups (CE, LAA, others) based on diagnostic workup.D-Dimer and Fibrinogen levels at admission were compared between groups using the Kruskal-Wallis test for mean differences and the Mann-Whitney test for post-hoc analysis.Additionally, a regression analysis was performed to explore the relationship between the biomarkers and age