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Notably, all model animals based on a HFD are associated with obesity and IR

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The basic idea is that fecal matter builds up in the colon and leads to autointoxication, which is "an ancient theory based on the belief that intestinal waste products can poison the body and are a major contributor to many, if not all, diseases," according to a report in the Journal of Clinical Gastroenterology

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Trauner M, Gulamhusein A, Hameed B, Caldwell S, Shiffman ML, Landis C, et al

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