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doi: 10.1177/2058738418820402 [DOI] [PMC free article] [PubMed] [Google Scholar] 295

These changes are driven by the placenta hormones estradiol and progesterone

(2023) found that GLP-1 receptor agonists reduced the risk of lower limb amputation by 43% compared to sulfonylureas (HR: 0.57, 95% CI: 0.390.84), with the greatest risk reduction observed in long-term users (HR: 0.44, 95% CI: 0.270.72).(26) However, GLP-1 receptor agonists did not significantly impact diabetic foot ulcer incidence (HR: 1.08, 95% CI: 0.871.35)