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In addition to its current applications in wound healing, infection control, and modulation of inflammation, further exploration of HA in diabetes mellitus could focus on its potential to regulate systemic metabolic dysfunction, including improving insulin sensitivity, protecting pancreatic -cells from oxidative stress, and modulating adipose tissue inflammation to alleviate insulin resistance

531 In osteosarcoma cells, zinc oxide nanoparticles can also be observed to increase the expression of HIF-1, mediate mitophagy through the HIF-1-BNIP3-LC3B pathway, and inhibit tumor growth, 532 along with tumor cell metastasis

Tripathi SM, Ramachandran R

Any drug-induced liver injury could alter the metabolism and clearance of both Ashwagandhas constituents and a patients concomitant endocrine medications (antithyroid drugs, corticosteroid replacement therapy), leading to unpredictable plasma levels and effect