2 L-serine and metabolic regulation 2.1 L-serine forms a complex metabolic network As a glycogenic amino acid, L-serine has various sources, such as an external diet, intracellular synthesis (from the glycolytic intermediate 3-phosphoglycerate and glycine), and cleavage of proteins and phospholipids in vivo ( in situ ( de novo synthesis, L-serine is converted from 3-phosphoglycerate (3-PG), an intermediate of glycolysis, through a three-step enzymatic reaction, in which 3-phosphoglycerate dehydrogenase (PHGDH) is the first rate-limiting enzyme ( Figure 1a ) ( Figure 1b ) ( Figure 1 Therefore, L-serine is a precursor molecule for the synthesis of many substances, and the metabolism of L-serine includes the synthesis of amino acids, phospholipids, and proteins ( Figure 1c ) ( Figure 1d ) ( Figure 1
AmannTMaegdefrauUHartmannAAgaimyAMarienhagenJWeissTSet al
Once your flare has resolved, you can reintroduce these items slowly
To investigate taxifolin effects, oxidant and antioxidant levels were measured in the brain tissues of the animals, and the latent period between epilepsy induction and seizure development was recorded