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Complementary modulation of somatic inhibition by opioids and cannabinoids

10.1016/j.ijrobp.2018.11.016 9 BarahmanM.ZhangW.HarrisH

The JNKs, specifically the JNK1 isoform, would be a direct inhibitor of the insulin receptor substrate 1, the substrate of the insulin receptor, being its activation cause for a reduction of insulin signaling and glucose up-take, an already described symptom of possible appearance of AD [5, 13, 96]