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RNA extraction, library construction, sequencing, and data analyses Total RNA was extracted from bulk cIECs isolated from mice using TRIzol reagent (Invitrogen)

However, due to the foreign nature of human genes being expressed in these mouse models, they often may become targets of murine miRNAs which may interfere with their expression in mice, for example, the CETP gene containing mouse or APOE*3-Leiden

55 and Aebi 56 method was used

Oxidants produced by mitochondria are thought to be the main origin of oxidative damage, and SOD2 in the mitochondrial matrix plays a vital role in antioxidants by catalysing the conversion of superoxide anion to H 2 O 2 [250]