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For example, bone morphogenetic proteins (BMPs) upregulate Runx2 expression through the small mothers against decapentaplegic (Smad) signaling pathway (77), while the Wingless-related integration site (Wnt)/-catenin signaling pathway enhances Runx2s transcriptional activity on osteogenic genes (78), further promoting osteoblast maturation

By inhibiting COX-2 and NF-B, MEL can reduce the release of inflammatory cytokines and chemokines (Sheikholeslami et al

P.et al (2003)

Furthermore, DEHP also has toxicity on other endpoints, such as mutagenicity, immunotoxicity, cytotoxicity, and hepatotoxicity, may related to long-term chronic accumulation, whereas respiratory toxicity, skin sensitization and eye corrosion are caused mainly by short-term high-dose exposure