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In our study, though we did not observe an obvious deacetylation of SKP2 by SIRT7, in future study, it would be interesting to evaluate whether SIRT7 also contributes to SKP2 protein stability via APC-Cdh1 E3 ubiquitin-ligase

The liver stores of ferritin are the primary physiologic source of reserve iron in the body

In Group B,44/76 (57.9%) had CCM at enrolment, of whom 5(11.4%) improved to normal diastolic function, and 12(27.3%) improved to Grade I LVDD (i.e., 38.7% of CCM had regression) ( P =0.009 for difference in CCM regression in Group A vs B)