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Moreover, emerging technologies such as targeted protein/RNA degradation methods (e.g., LYTAC, ATTEC), as well as novel approaches targeting cell substructures (exosomes, lysosomes), nuclear export pathways, the cell membrane, and RNA molecules, offer promising opportunities for advancing medicinal chemistry

A #14 mutant with significantly higher glutathione content was isolated via acrolein resistance screening

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A high GSH concentration and a reduced cellular state are known to promote self-renewal, allowing the GSH-to-ROS ratio to be a key determinant of cell fate (Zhou et al., 2016)