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These enzymes generate numerous potent reactive oxygen (ROS)and nitrogen species (RNS) that can damage DNA and RNA, leading to increased mutations and thus contributing to the multistage carcinogenesis process ( Fig

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Given the hypothesized dysfunction of the NMDA receptor in schizophrenia, efforts to enhance glycinergic neurotransmission through GlyT1 inhibition gained traction as a therapeutic strategy

Here we report the development of a new redox buffer based on MESNA and its oxidized disulfide 2,2-dithiobis(ethanesulfonate) (diMESNA) that shows a refolding efficiency that is comparable to that of the glutathione redox couple