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Considering the role of autophagy in both adaptive and innate immunity [28,29] , autophagy is vital for glial functions related to controlling inflammatory signalling, eradicating pathogens, sustaining immune modulators, and modifying antigen presentation in various neurodegenerative diseases

These somatic and signaling abnormalities are accompanied by increased oxidative stress associated with mitochondrial dysfunction both in ASD and AD [353]

The BCG vaccines mechanism of action contains stimulating a robust immune response against the tuberculosis bacillus

mTOR aggravated CD4+ T-cell pyroptosis by regulating the PPAR-Nrf2 pathway in sepsis