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(Ye et al., 2009

4 Relevant mechanisms affecting the occurrence of cuproptosis 4.1 Copper overload disrupts the synthesis of Fe-S cluster proteins Fe-S clusters are cofactors made up of iron and inorganic sulfur, which play a crucial role in a variety of biological processes, including mitochondrial energy production, amino acid synthesis, cofactor synthesis, and tRNA modification (Lill, 2009)