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[1] Tesofensine was originally developed by a Danish biotechnology company, NeuroSearch, who transferred the rights to Saniona in 2014

The FDA first added semaglutide to its shortage list in March 2022, followed by tirzepatide in December 2022, and liraglutide in July 2023 (U.S

Mechanisms underlying neuroprotection include enhanced cerebral angiogenesis supporting tissue oxygenation, anti-inflammatory effects reducing secondary injury, antioxidant activity limiting free radical damage, and modulation of neurotransmitter systems including the dopamine/glutamate/NO system