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However, there was a significant absolute change ( P = 0.008) in the Comp score for participants supplemented with L-Carnitine-combination at the end of the study, and this was greater compared to the placebo group ( P = 0.013)

124 Additionally, the loss of transmembrane p24 trafficking protein 4 (TMED4)-induced ROS reduces FOXP3 stability and the suppressive function of Tregs in an IRE1/XBP1 axisdependent manner 125 (Fig