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2012;7(5):e37960

42 Notably, the discovery of RNA-dependent RNA polymerase and reverse transcriptase has been crucial for developing subsequent mRNA drugs

Following discovery of a sparse number of occurrences of progressive multifocal leukoencephalopathy (PML) in those taking a FAE, median duration of FAE therapy to PML symptom onset or appearance of first PML brain lesion was 31 months (range 6110), with median duration of lymphocytopenia to PML symptoms being 23 months (range 672)