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Reagents The following reagents were used for cell stimulation: deferoxamine (0.1-20 M, Sigma, D9533), -thujaplicin (Hinokitol, Sigma, 469521), deferasirox (Exjade, Novartis), fe(III) sulfate hydrate (2-20 M, Sigma, F0638), arachidonic acid (AA, 20 M, Sigma, A3611), docosahexaenoic acid (DHA, 500 M, Sigma, D2534), palmitic acid (PA, 250 M, Sigma, P5585), oleic acid (OA, 250 M, Sigma, O1008), palmitoleic acid (POA, 100 M, Sigma P9417), stearidonic acid (SDA, 50 M, Sigma SMB00291), eicosapentaenoic acid (EPA, 100 M

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SSc is a rare autoimmune disease with fibrotic pathology manifesting in the skin and internal organs such as the lungs and heart [25,26,27]

The key question remaining is whether long-term outcomes match those of traditional immunotherapy, which can provide decades-long remission in some patients