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After demonstrating the transcriptional augmentation of SIRT3 by Rd, C-C and Compound A (C-A) were employed to inhibit AMPK and ERR respectively, and the treatment blocked the enhancing effects of Rd (Fig

Consistency of Administration Since the olfactory region has a small surface area (~ 510 cm 2 ) and is located in the upper part of the nasal cavity, targeting this region can be challenging and result in improper dosing [79]

When NAC was given alone, it accelerated senescence and shortened the lifespan of the nematode worm Caenorhabditis elegans [27]

Furthermore, circulating miR-30 levels are positively correlated with left ventricular wall thickness, potentially serving as an important marker for diagnosing hypertrophy associated with excessive autophagy [37]