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Methylfolate is the only metabolite of folate that can cross the blood-brain barrier, and plays a key role in cell metabolism, protein methylation, and the synthesis of the monoamine neurotransmitters

High Se status was associated with decreased risk of hyperglycemia and type 2 diabetes, while other studies also reported that high serum Se concentration favored increased prevalence of diabetes male participants followed over 9 years

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Folate deficiency leads to the accumulation of homocysteine which is associated with an increased risk of cerebrovascular diseases, depression, and dementia, with a focus on vascular dementia and Alzheimers disease (, , )