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Beta-oxidation produces acetyl fragments from the fatty acid molecule in the form of acetyl-Coenzyme A (acetyl CoA), which enters the Krebs (Citric acid) cycle and participates in the formation of ATP energy

When the peroxidation of a PLOOH molecule is not catalyzed by glutathione peroxidase 4 (GPX4) to form the corresponding alcohol (a PLOH), the PLOOH and lipid radicals, especially PLOO and alkoxy phospholipid radicals (PLO), continue to drive the dehydrogenation of PUFA-PLs and to react with oxygen through the Fenton reaction to generate a large number of PLOOH molecules [5, 15, 44, 45]

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