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Furthermore, after receiving the LH signal, the CGCs depolarized, increasing the intracellular calcium ion(Ca2+)concentration (35)

In response to extracellular ATP, the P2X 7 purinergic receptors may shift from rapid-gating channels selective for small cations to more slowly developing dilated pore conformations permeable to molecules up to 900 Da (North, 2002) and thus facilitate glutamate release under pathological conditions (Duan et al., 2008