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The Sun 2021 study used the APP/PS1 transgenic mouse model of Alzheimers disease, with intragastric administration of Dihexa at 1.44 mg/kg or 2.88 mg/kg once daily for three months (six to nine months of age in the APP/PS1 cohort)

These upregulated genes include the fetC , frtA reductive iron assimilation (RIA) genes, elements of the Siderophore (but not the SidC) cluster, as well as amcA mitochondrial ornithine carrier protein (supporting siderophore biosynthesis by ornithine [61], and mirC , sit1 siderophore transporter genes (Fig