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Cisplatin was administered intravenously at a dose of 75 mg/m2 approximately 30 minutes after pemetrexed for injection administration on Day 1 of each cycle, gemcitabine was administered at a dose of 1250 mg/m2 on Day 1 and Day 8, and cisplatin was administered intravenously at a dose of 75 mg/m2 approximately 30 minutes after administration of gemcitabine, on Day 1 of each 21- day cycle

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Alternatively, it can result from a tumor in the pituitary gland, causing it to produce too much ACTH a hormone that signals your adrenals to release cortisol