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Mehta et al., 2020) that can cause acute respiratory distress syndrome, lung injury, respiratory insufficiency, endothelial cell dysfunction, thrombosis, cardiovascular disease and end-organ damage (Klok et al., 2020

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We applied an unsupervised principal component analysis (PCA) to assess class (genotype and/or treatment) homogeneity and to identify outliers, and then, we used a supervised OPLS-DA (orthogonal partial least squares discriminant analysis) to evaluate class discrimination and highlight metabolic differences associated with Tbx1 mutation