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Latest treatments have been developed to treat all these imperfections and flaws

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Fallon RF, Goodenough DA

reported that AS-IV reduces the amplitude of L-type Ca 2+ current in guinea pig ventricular cells in a concentration-dependent manner, influencing L-type Ca 2+ channel kinetics, suppressing channel activity, and blocking Ca 2+ current, while concurrently inhibiting K + current to prolong APD (Zhao et al., 2013)