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For additional information regarding the use of old work time values that were established many years ago and have not since been reviewed in our methodology, we refer readers to our discussion of the subject in the CY 2017 PFS final rule (81 FR 80273 through 80274)

Cysteine concentrations are regulated by a balance between the rates of its synthesis through the transsulfuration pathway and its metabolism to GSH, inorganic sulfate, or taurine (27,28)

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Its efficacy stems from its ability to directly modulate numerous signaling pathways and molecular targets critical to the inflammatory cascade