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AE also acknowledges funding from the European Union for HORIZON 2022 fLIMAGING3D (101073507) and HILIGHT (101135034, backed by Innovate UK as project number 10107542)

Decreased levels of red blood cell reduced glutathione (RBC-GSH) and increased levels of oxidized glutathione have been observed in hypertensive patients, resulting in an elevated ratio of oxidized to reduced glutathione compared to controls

Ibuprofen, in particular, possesses Nf-kB inhibitory activity that may further help reducing excess inflammation/cytokine release in COVID-19 patients ( there is no evidence supporting the association between Ibuprofen and increased risk of severity of COVID-19 , a position strengthened by a systematic review appeared 2 months later ( Several studies are accumulating and reappraising the importance of NSAIDs in COVID-19 management ( in silico screenings independently identified the COX-II inhibitor celecoxib as a potential anti-SARS-CoV-2 drug, and a very recent study still under peer review reports its beneficial effects plus famotidine in hospitalized patients ( Despite this accumulating evidence, paracetamol (PAC) was suggested as a safer and recommendable alternative for the early and domiciliary management of pain and fever in COVID-19 patients

It comes from the dried root of the Glycyrrhiza glabra plant and is a popular traditional herbal medicine used to treat many conditions