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Gregory Lubiniecki, vice president of oncology clinical research at Merck Research Laboratories, noted in a statement that prognoses are generally poor for this disease and said the company is pleased to offer a new first-line treatment option. The approval was backed by results from the Phase II/III KEYNOTE-483 trial, where Keytruda elicited a significant survival benefit for patients, cutting the risk of death by 21%

Reviewing previous IBD treatment response: If a biologic or advanced IBD treatment has not worked as expected, it may be appropriate to review treatment history, disease activity, drug levels, antibodies, timing of response and whether symptoms are due to inflammation or an overlapping condition

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However, if serious nerve damage symptoms persist for months and years, they might become permanent