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490,491,492 Additionally, they are feasible to be engineered with specific modifications to accurately target lesion sites and realize prolonged retention at the exact locations

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Also, in the case of 3D cultures, Western blotting analysis demonstrated that angiotensin-converting enzyme and CD40 were upregulated, and that sirtuin 1 and sirtuin 6 were inhibited after TNF- treatment

Therefore, some EDCs may be expected to accumulate in the gut in vivo , exposing the microbiota to higher concentrations and/or for longer periods of time