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however, it did not significantly differ between IV and PO at the same dosage." The cause of LAP - pressure build-up in the left atrium - is excess fluid, in this case, blood regurgitated back through the faulty mitral valve

1 H NMR (400 MHz, DMSO- d 6 ) 12.44 (s, 1H), 11.13 (s, 1H), 9.98 (s, 1H), 7.78 (dt, J = 16.5, 8.1 Hz, 2H), 7.64 (d, J = 7.0 Hz, 1H), 7.41 (d, J = 3.4 Hz, 1H), 6.73 (d, J = 6.5 Hz, 1H), 5.12 (dd, J = 12.7, 5.4 Hz, 1H), 4.04 (d, J = 19.6 Hz, 2H), 3.53 (d, J = 10.5 Hz, 2H), 3.15 (t, J = 7.1 Hz, 2H), 3.062.98 (m, 2H), 2.962.83 (m, 3H), 2.74 (dd, J = 21.0, 9.4 Hz, 1H), 2.60 (d, J = 19.4 Hz, 1H), 2.572.52 (m, 1H), 2.091.87 (m, 5H), 1.68 (d, J = 6.8 Hz, 4H), 1.47 (s, 2H), 1.33 (s, 4H), 1.21 (d, J = 17.8 Hz, 9H)

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