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Microwave tumors ablation: principles, clinical applications and review of preliminary experiences

4.3 Coumarins Bergapten, a natural coumarin derivative, has emerged as a promising therapeutic agent for renal fibrosis

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Erastin-induced ferroptosis was reduced by the antioxidant trolox.7,82 Additional drugs shown to decrease erastin-induced ferroptosis include ebselen (glutathione peroxidase mimetic) and the MEK inhibitor U0126,7 as well as baicalein which suppressed erastin-mediated GPX-4 degradation in pancreatic cancer.84 Rosiglitazone has ACSL4 inhibitor y effect and prolongs survival in GPX4/ mice.31 While the drug is no longer available for clinical use for diabetes in Europe due to safety concerns, the short term and even single dose use needed in AKI may be safe