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DeFeudis Professor of Biomedical Research University of Massachusetts Medical School Copyright 2015-2026 Linus Pauling Institute Figure Alternative Text Figure

These features include a shortened effective atrial refractory period, delayed atrial conduction, and increased reentrant excitation, all of which are closely associated with alterations in atrial structure and function ( 2.3 Signaling mechanisms in atrial cardiomyopathy The development of ACM is closely related to the electrophysiological activity of the atria, particularly the atrial remodeling process

By inhibiting autophagy and inducing mitochondrial ROS, TMAO activates NLRP3 inflammasome, leading to the release and pyroptosis of IL-1/IL-18 dependent on caspase-1 in colon epithelium, which is a hallmark of IBD severity

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