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1 DN is believed to be associated with neuronal, neuroglial cell and vascular endothelial cell injury caused by uncontrolled hyperglycemia, dyslipidemia and IR through multiple pathways, such as ERS, inflammation, oxidative stress and mitochondrial disorders

Annu Rev Virol 3(1):237261 Ziebuhr J (2004) Molecular biology of severe acute respiratory syndrome coronavirus

At these higher doses, Vitamin C acts as a powerful antioxidant and immune-modulating agent

The complex travels through the small intestine until it reaches the terminal ileum, where specialised receptors called cubam (a complex of cubilin and amnionless proteins) recognise and facilitate the uptake of the B12-IF complex into enterocytes (intestinal cells)