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Telomeres (the protective caps at the end of DNA strands) also become damaged, which is another factor that contributes to premature aging and all the health risks that come with it

Cancer Sci 106:635641

To deal with the extra ROS, mitochondria developed an antioxidant system to counteract the massive buildup of ROS and avoid oxidative stress

These results provide further evidence that the elimination of intracellular Ca 2+ prevents apoptosis induced by H 2 O 2 in Prx II-knockdown HaCaT cells