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Uremic toxins induce kidney fibrosis by activating intrarenal renin-angiotensin-aldosterone system associated epithelial-to-mesenchymal transition

But the second part of the equation with the FDA is approving efficacy and approving efficacy

Elife 13:RP96890 Chatterjee N, Bohmann D (2012) A versatile C31 based reporter system for measuring AP-1 and Nrf2 transcriptional activity in Drosophila