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The synergistic cytotoxic effects of NAR and ferroptosis inducers were reversed when the cells were pretreated with AMPK inhibitors or PGC1 inhibitors, confirming that the inhibition of aerobic glycolysis mediated through the AMPK-PGC1 signaling pathway is crucial for NAR reducing liver cancer resistance to ferroptosis ( 3.2.3 Hesperidin and hesperetin Hesperidin (HSD) is a subgroup of citrus flavonoids, primarily extracted from bitter orange peel powder (146)

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We are thankful to Dr Jean Kim and the Human Stem Cell Core at Baylor College of Medicine for mediating the cell transfer, Dr Tobias Dick for Grx1-roGFP2 plasmid, and Drs Vsevolod Belousov, Luke Lavis, and Catherine Goodman for thoughtful discussions