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To date, 17 double-blind, randomized, placebo-controlled trials of mitochondrial modulators such as N -acetylcysteine and inositol in treating OCD have been conducted (Table 1)

Using a 90-degree angle, quickly insert needle into the pinched skin

Animals were fed ad libitum a diet prepared according to the American Institute of Nutrition (AIN-93M) for adult rats (Reeves et al., 1993)

Furthermore, to prevent irritation and maintain microbial defense, the pH of the nasal formulation should be adjusted slightly acidic, as lysozymes in nasal secretions effectively destroy bacteria at acidic pH but become inactivated under alkaline conditions, leaving tissue vulnerable to infection [101]