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4-Hydroxynonenal 4-Hydroxynonenal (4HNE) is a lipoperoxidation-derived aldehyde that can damage proteins and DNA through the generation of covalent adducts and is implicated in the control of cell signaling 13,14

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GPX2 and GPX3 exert antioxidant effects in intestinal epithelial cells and plasma, respectively [65]

POD1 , another APXs genes, has the same expression is same as APx1 induced by abio-stress [28]